A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

Abstract: Adenosine triphosphate (ATP) is the energy currency of the body; it takes part in various and indispensable metabolic processes for the maintenance of cell homeostasis, degrading to its hydrolysis product, adenosine diphosphate (ADP). Efficient ways to restore ATP are therefore necessary in the cells. When the cell lacks energy due to ischemic conditions or high ATP demand, phosphocreatine gives its phosphate group to ADP that converts to ATP, in a reaction catalyzed by the enzyme creatine kinase. For this reason, phosphocreatine is utilized as a pharmacological treatment in human diseases that involve a failure of the cellular energy, most notably in coronary artery disease.

Link to article: https://www.eurekaselect.com/article/87002

PubMed:  https://pubmed.ncbi.nlm.nih.gov/29165089/

Authors: Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino, and Enrico Millo

Key Terms: General Creatine, Non-CCDS Diseases, Basic Science