Creatine metabolism in psychosis and catatonia: A case report and review of the literature

Abstract: Background: In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation. Basic Procedures and Main Findings: We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency. Principal Conclusions: This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.

Parent Summary: This case report describes the first known instance of psychotic and catatonic symptoms in a patient with AGAT deficiency, a disorder affecting brain creatine synthesis. The patient required creatine supplementation, and their symptoms support a link between disrupted brain creatine metabolism and the development of severe psychiatric features. This finding broadens the clinical understanding of AGAT deficiency and highlights the importance of considering metabolic causes in psychiatric presentations.

Link to article: https://www.sciencedirect.com/science/article/pii/S2773021225000173?via%3Dihub

PubMed:  https://pubmed.ncbi.nlm.nih.gov/26122200/

Authors: Sophie Scharner, Terrance M Dolan, Eric P Hazen

Key Terms: AGAT, Clinical Study, Supplements, Pediatric Patient, Male Patient