Creatine monohydrate supplementation for older adults and clinical populations

Abstract: Background: The biological process of aging is typically associated with a decrease in muscle quantity, muscle performance (primarily strength), bone mass and architecture, functionality and neurological/cognitive function. From a healthy aging perspective, interventions that have the potential to overcome or attenuate these decrements are clinically relevant. Methods: We conducted a narrative review on the efficacy of creatine monohydrate supplementation (CrM) in older adults. Results: Accumulating research shows that CrM, primarily when combined with exercise training, is safe and has beneficial effects on measures of whole-body lean body mass, regional muscle size, muscle strength, bone area and thickness, functional ability, glucose kinetics, cognition and memory. Conclusion: CrM has multiple benefits in older adults and may have application for treating age-related sarcopenia, osteoporosis, frailty, and those with metabolic and neuromuscular disorders.

Link to article: https://www.tandfonline.com/doi/full/10.1080/15502783.2025.2534130#abstract

PubMed: https://pubmed.ncbi.nlm.nih.gov/40673730/

Authors: Darren G. Candow, Sergej M. Ostojic, Philip D. Chilibeck, Igor Longobardi, Bruno Gualano, Mark A. Tarnopolsky, Theo Wallimann, Terence Moriarty, Richard B. Kreider, Scott C. Forbes, Uwe Schlattner & Jose Antonio

Key Terms: General Creatine, Supplements, Basic Science