Cerebral Creatine Deficiency Syndromes (CCDS) are rare genetic conditions that prevent the brain from properly producing or transporting creatine, a molecule essential for brain energy and development.

Children with creatine deficiencies often experience:

• Developmental delays

• Speech and language impairment

• Intellectual disability

• Seizures

• Behavioral challenges

Because these disorders are rare and underdiagnosed, families frequently struggle for years before receiving a diagnosis. Research funded through ACD is helping scientists better understand these disorders and develop therapies that could transform lives.