HolidayHeroes - Association for Creatine Deficiencies

Give Hope to Families Affected by Creatine Deficiencies

Children with CCDS need our help to ensure science is moving steadily toward treatments and a cure. This holiday season, that cure is within reach. Be a Holiday Hero this season and help us create an ‘avalanche of hope.’

100% of funds donated to Holiday Heroes are dedicated to research.

ACD has already committed more than $7.6 million toward research since our founding in 2012, with over $5.1 million invested in 2026 alone! Your Holiday Heroes donation keeps us moving forward as we fight to CURE CREATINE DEFICIENCIES.

How you can make a difference:

Start a Holiday Heroes team and receive a fundraising guide – we will support you along the way
Make a donation to Holiday Heroes and help us reach our $350,000 goal
Support a child on our snowflake wall and help a family reach their goal
Follow us on Facebook and Instagram to reshare our posts and spread our mission.

Your Donation Supports Research

UC Berkeley

1-year research award to accelerate the development of a novel method to deliver a key enzyme directly into cells to enable creatine production in individuals with GAMT deficiency.

Johns Hopkins University

2-year research investment to accelerate their work to deliver creatine to the brain, including to neurons, using dendrimer nanoparticles, without the need of a creatine transporter, to help patients with CTD.

Stanford University

2-year research award to build upon their work developing new ways to deliver creatine directly into cells without relying on the faulty transporter protein that causes CTD.

Ultragenyx

Investment in the preclinical development of a therapy for Creatine Transporter Deficiency (CTD) with a total commitment of $4 million as the program progresses.

Research Fellowship

Help us award our 6th year of research fellowships supporting 12 months of CCDS research for young researchers establishing their careers.

CTD Newborn Screening Research

Support assay development for CTD newborn screening technology enabling advocacy for early diagnosis of Creatine Transporter Deficiency.

Give to Join the Avalanche of Hope!

2026 Holiday Heroes donations accepted starting November 1st. Want to give now? Support our mission here.

Register Your Holiday Heroes Team

Team registration opens October 1st. Check back soon.

Support a Child on Our Snowflake Wall

Every family has set a goal to raise at least $500 by December 31st. Select a snowflake to learn more about each child and their family, then join the avalanche of hope and help them reach their goal!